A series of interconnected short films are the backdrop for a maniac screenwriter who pitches insane storylines featuring some of Hollywood's biggest and brightest. In some countries, like the United Kingdom and the Netherlands, the structure differs. Instead of a pitch, the films are connected by a group of three teenagers searching for the most banned film in the world, Movie 43, which will ultimately lead to the destruction of civilization.
Charlie Wessler (segment "The Pitch")
Dennis Quaid
Griffin Schraeder (segment "The Pitch")
Greg Kinnear
Davis (segment "The Catch")
Hugh Jackman
Beth (segment "The Catch")
Kate Winslet
Kevin (segment "Homeschooled")
Jeremy Allen White
Robert (segment "Homeschooled")
Liev Schreiber
Samantha (segment "Homeschooled")
Naomi Watts
Vanessa (segment "The Proposition")
Anna Faris
Jason (segment "The Proposition")
Chris Pratt
Neil (segment "Veronica")
Kieran Culkin
Veronica (segment "Veronica")
Emma Stone
Robert (segment "iBabe")
Richard Gere
Arlene (segment "iBabe")
Kate Bosworth
Fake Robin (segment "Super Hero Speed Dating")
Justin Long
Fake Batman (segment "Super Hero Speed Dating")
Jason Sudeikis
Fake Lois Lane (segment "Super Hero Speed Dating")
Uma Thurman
Fake Superman (segment "Super Hero Speed Dating")
Bobby Cannavale
Fake Supergirl (segment "Super Hero Speed Dating")
Kristen Bell
Fake Penguin (segment "Super Hero Speed Dating")
John Hodgman
Fake Wonder Woman (segment "Super Hero Speed Dating")
Leslie Bibb
Fake Riddler (segment "Super Hero Speed Dating")
Will Carlough
Woman (segment "Super Hero Speed Dating")
Katrina Bowden
Narrator (segment "Machine Kids") (voice)
Phil Crowley
Mikey (segment "Middleschool Date")
Christopher Mintz-Plasse
Amanda (segment "Middleschool Date")
Chloë Grace Moretz
Dad (segment "Middleschool Date")
Patrick Warburton
Nathan (segment "Middleschool Date")
Jimmy Bennett
Amanda's Dad (segment "Middleschool Date")
Matt Walsh
Leprechaun 1 & 2 (segment "Happy Birthday")
Gerard Butler
Pete (segment "Happy Birthday")
Johnny Knoxville
Pete (segment "Happy Birthday")
Seann William Scott
Emily (segment "Truth or Dare")
Halle Berry
Donald (segment "Truth or Dare")
Stephen Merchant
Coach Jackson (segment "Victory's Glory")
Terrence Howard
Amy (segment "Beezel")
Elizabeth Banks
Anson (segment "Beezel")
Josh Duhamel
Bob Mone (segment "The Pitch")
Common
Jay (segment "The Pitch")
Charlie Saxton
Jerry (segment "The Pitch")
Will Sasso
Danita (segment "The Pitch")
Odessa Rae
Seth MacFarlane (segment “The Pitch”)
Seth MacFarlane
Mike Meldman (segment "The Pitch")
Mike Meldman
Pamela (segment "The Catch")
Julie Claire
Angie (segment "The Catch")
Katie Finneran
Ray (segment "The Catch")
Roy Jenkins
Jake, the Waiter (segment "The Catch")
Rocky Russo
Abby (segment "The Catch")
Anna Madigan
Sean (segment "Homeschooled")
Alex Cranmer
Clare (segment "Homeschooled")
Julie Ann Emery
High School Student (segment "Homeschooled")
Austin Cope
Larry (segment "The Proposition")
JB Smoove
Bill (segment "The Proposition")
Jarrad Paul
Christine (segment "The Proposition")
Maria Arcé
Friend (segment "The Proposition")
Aaron LaPlante
Old Man (segment "Veronica")
Arthur French
Tall Lady (segment "Veronica")
Brooke Davis
Short Guy (segment "Veronica")
Josh Shuman
iBabe #1 (segment "iBabe")
Cathy Cliften
iBabe #2 (segment "iBabe")
Cherina Monteniques Scott
Brian (segment "iBabe")
Jack McBrayer
Robert (segment "iBabe")
Aasif Mandvi
Boy (segment "iBabe")
Zach Lasry
Woman (segment "iBabe")
Darby Lynn Totten
"Chappy" (segment "iBabe")
Marc Ambrose
Vending Machine Man (segment "Machine Kids")
Ed Blythe
Vending Machine Child (segment "Machine Kids")
Olivia Roberts Payne
Vending Machine Child (segment "Machine Kids")
Monique Delee
ATM Woman (segment "Machine Kids")
Julie McNiven
ATM Man (segment "Machine Kids")
Jaron Henrie-McCrea
ATM Child (segment "Machine Kids")
Sebastian Banes
ATM Child (segment "Machine Kids")
Severyn Banes
Photocopier Man 1 (segment "Machine Kids")
Rightor Doyle
Photocopier Man 2 (segment "Machine Kids")
Raven Burnett
Photocopier Child (segment "Machine Kids")
Montana Byrne
Photocopier Child (segment "Machine Kids")
Jarrett Carter
Photocopier Child (segment "Machine Kids")
Phillip Michaels
Blonde Woman (segment "Tampax")
Coleen Hoffman
Brunette Woman (segment "Tampax")
Elbe Van Der Merwe
Fairy (segment "Happy Birthday")
Esti Ginzburg
Large Man (segment "Truth or Dare")
Sayed Badreya
Snooki (segment "Truth or Dare")
Snooki
Waitress (segment "Truth or Dare")
Caryl Lippman West
Nurse Elizabeth (segment "Truth or Dare")
Ricki Lander
Bachelorette Party Girl (segment "Truth or Dare")
Paloma Felisberto Bilson
Patron (segment "Truth or Dare")
Jasper Grey
Blanco the Bartender (segment "Truth or Dare")
Benny Harris
Stripper (segment "Truth or Dare")
Zen Gesner
Anthony (segment "Victory's Glory")
Aaron Jennings
Moses (segment "Victory's Glory")
Jared Dudley
Wallace (segment "Victory's Glory")
Corey Wayne Brewer
Bishop (segment "Victory's Glory")
Larry Eugene Sanders II
Lucious (segment "Victory's Glory")
Jay Ellis
White Guy 1 (segment "Victory's Glory")
Brian Flaccus
White Guy 2 (segment "Victory's Glory")
Brett Davern
White Guy 3 (segment "Victory's Glory")
Evan Dumouchel
White Guy 4 (segment "Victory's Glory")
Sean A. Rosales
White Guy 5 (segment "Victory's Glory")
Logan Holladay
Cheerleader (segment "Victory's Glory")
Mandy Kowalski
Narrator (segment "Victory's Glory")
Eric Stuart
Birthday Girl (segment "Beezel")
Emily Alyn Lind
Mommy (segment "Beezel")
Michelle Gunn
Party Clown (segment "Beezel")
Christina Linhardt
Calvin Cutler (segment "The Thread")
Mark L. Young