The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.
Spider-Man / Peter Parker
Tobey Maguire
Mary Jane Watson
Kirsten Dunst
New Goblin / Harry Osborn
James Franco
Sandman / Flint Marko
Thomas Haden Church
Venom / Eddie Brock
Topher Grace
Gwen Stacy
Bryce Dallas Howard
May Parker
Rosemary Harris
J. Jonah Jameson
J.K. Simmons
Captain Stacey
James Cromwell
Dr. Curt Connors
Dylan Baker
Emma Marko
Theresa Russell
Joseph 'Robbie' Robertson
Bill Nunn
Maître D'
Bruce Campbell
Miss Brant
Elizabeth Banks
Hoffman
Ted Raimi
Penny Marko
Perla Haney-Jardine
Green Goblin / Norman Osborn
Willem Dafoe
Ben Parker
Cliff Robertson
Mr. Ditkovitch
Ilya Baskin
Ursula
Mageina Tovah
Houseman
John Paxton
Mrs. Stacy
Becky Ann Baker
Man in Times Square
Stan Lee
Dennis Carradine / Carjacker
Michael Papajohn
Flash Thompson
Joe Manganiello
Anchorman
Hal Fishman
Jennifer Dugan
Lucy Gordon
Photographer
Steve Valentine
Play Director
Tim Maculan
Play Producer
Marc Vann
Jazz Club Manager
Joe Bays
Precinct Detective
Gregg Daniel
Emergency Room Doctor
Rogelio T. Ramos
Crane Operator
Timothy Patrick Quill
Kid in Times Square
Menachem Mendel Boymelgreen
Kid in Times Square
Nasir Stewart
Kid in Times Square
Austin Hendrickson
Kid in Times Square
Taylor Hemhauser
Woman Outside Theater
Kathryn Bryding
Police Detective
Joe Virzi
New Jersey State Policeman
Bill E. Rogers
New Jersey State Policeman
Michael Alexander
Test Site Technician
April Parker Jones
Test Site Technician
Edward Padilla
Test Site Technician
Robert Curtis Brown
Test Site Technician
Paul Terrell Clayton
Test Site Technician
Carolyn Neff
Test Site Technician
Christina Cindrich
ICU Nurse
Sonya Maddox
Crane Disaster Radio Policeman
Andre B. Blake
Cop at Crane Disaster
Derrick 'Phoenix' Thomas
Mary Jane's Replacement
Jessi Collins
Boy at Key to the City Ceremony
Michael McLaughlin
Councilwoman
Anne Gartlan
Policeman at Sand Truck
Emilio Rivera
Policeman at Sand Truck
Keith Woulard
Armored Car Driver
Reynaldo Gallegos
Newstand Patron
Jim Coope
Newsstand Patron
Dean Edwards
Newsstand Patron
Margaret Laney
Congratulatory Woman at Daily Bugle
Toni Wynne
Coffee Shop Waitress
Aimee Miles
Jazz Club Waitress
Tanya Bond
Jazz Club Bouncer
Mark Kubr
Girl With Camera
Emma Raimi
Boy at the Final Battle
Lorne Raimi
Boy at the Final Battle
Henry Raimi
Jazz Club Musician
Alan Cohn
Jazz Club Musician
Dan Callahan
Jazz Club Musician
Daniel Cummings
Jazz Club Musician
Ron King
Jazz Club Musician
Carol Chaikin
Jazz Club Musician
Vance Hammond
NYPD Officer (uncredited)
Frank Anello
Model (uncredited)
Anya Avaeva
Bucket Boy (uncredited)
David Backus
Photoshoot Client (uncredited)
Tony Besson
Photographer (uncredited)
Michael Ciesla
Jazz Club Waitress (uncredited)
Irina Costa
Theater Patron (uncredited)
John Crann
Jazz Club Girl (uncredited)
Crystal Marie Denha
Columbia Grad Student (uncredited)
Amy V. Dewhurst
Pedestrian (uncredited)
Keith Fausnaught
Automobile Driver (uncredited)
Logan Fry
News Spectator (uncredited)
Tony Galtieri
News Reporter (uncredited)
Brian Hopson
Jazz Club Bouncer (uncredited)
Andrew James Jones
Girl at Key Ceremony (uncredited)
Natalie Jones
Student (uncredited)
Christopher Jude
ER Nurse (uncredited)
Brittany Krall
Woman in Court (uncredited)
Pierangeli Llinas
British Publicist (uncredited)
Bernadette Lords
Girl Screaming in Camaro (uncredited)
Natalie McNeil
Oscorp Receptionist (uncredited)
Martha Millan
Girl in Times Square (uncredited)
Michele-Nanette Miller
Robbie's Assistant (uncredited)
Claudia Katz Minnick
Beautiful Girl (uncredited)
Jen Oda
Beautiful Woman (uncredited)
Anjelia Pelay
Police Officer (uncredited)
Nick Poltoranin
Beautiful Woman (uncredited)
Vanessa Reseland
Beautiful Woman (uncredited)
La Rivers
Businesswoman (uncredited)
Bria Roberts
Sandman Victim (uncredited)
Vanessa Ross
Bad Girl (uncredited)
Brenna Roth
City Hall Cheerer (uncredited)
Shade Rupe
Jazz Club Guest (uncredited)
Daniel Shafer
Café Girl (uncredited)
Abbey Skinner
Jazz Club Patron (uncredited)
Kristin Somo
Jazz Club Waitress (uncredited)
Jennifer Sparks
NY Firefighter (uncredited)
Christopher Stadulis
Model (uncredited)
Aija Terauda
Beautiful Woman (uncredited)
Evelyn Vaccaro
Bar Patron #5 (uncredited)
Nick Vlassopoulos
Model (uncredited)
Sincerely A. Ward
ER Nurse (uncredited)
Jennifer Weston
Spectator (uncredited)
Ray Wineteer
Beautiful Woman (uncredited)
Emily Eckes
Girl at the Final Battle
Samantha Ressler
Radioman (uncredited)
Craig 'Radio Man' Castaldo