When their trip to San Lorenzo takes a turn for the worst, Arnold and his classmate’s only hope of getting home is retracing the dangerous path that led to Arnold's parents' disappearance.
Arnold (voice)
Mason Cotton
Gerald (voice)
Benjamin Flores Jr.
Helga (voice)
Francesca Marie Smith
Phoebe (voice)
Anndi McAfee
Eduardo (voice)
Carlos Alazraqui
La Sombra (voice)
Alfred Molina
Harold (voice)
Justin Shenkarow
Stella (voice)
Antoinette Stella
Nadine (voice)
Laya DeLeon Hayes
Paulo (voice)
Jamil Walker Smith
Olga (voice)
Nika Futterman
Rhonda (voice)
Olivia Hack
Che (voice)
Lane Toran
Mr. Simmons (voice)
Dan Butler
Grandpa (voice)
Dan Castellaneta
Grandma (voice)
Tress MacNeille
Bob Pataki (voice)
Maurice LaMarche
Ernie (voice)
Dom Irrera
Miriam (voice)
Kath Soucie
Big Patty (voice)
Danielle Judovits
Stoop Kid (voice)
Danny Cooksey
Coach Wittenberg (voice)
Jim Belushi
Miles (voice)
Craig Bartlett
Eugene (voice)
Gavin Lewis
Stinky (voice)
Jet Jurgensmeyer
Sid (voice)
Aiden Lewandowski
Curly (voice)
Nicolas Cantu
Oskar (voice)
Wally Wingert
Pigeon Man (voice)
Stephen Stanton