Ten years after the original Woodsboro murders, one of the survivors returns home to promote their new book about surviving trauma, only for a new Ghostface killer to emerge, targeting a new group of teens.
Dewey Riley
David Arquette
Sidney Prescott
Neve Campbell
Gale Weathers-Riley
Courteney Cox
Jill Roberts
Emma Roberts
Kirby Reed
Hayden Panettiere
Deputy Perkins
Anthony Anderson
Deputy Hoss
Adam Brody
Charlie Walker
Rory Culkin
Kate Roberts
Mary McDonnell
Deputy Judy Hicks
Marley Shelton
Rebecca Walters
Alison Brie
Olivia Morris
Marielle Jaffe
Trevor Sheldon
Nico Tortorella
Robbie Mercer
Erik Knudsen
Rachel
Anna Paquin
Chloe
Kristen Bell
Sherrie
Lucy Hale
Trudie
Shenae Grimes-Beech
Marnie Cooper
Britt Robertson
Jenny Randall
Aimee Teegarden
'The Voice' (voice)
Roger L. Jackson
TV Host
Nancy O'Dell
Film Geek
Justin Michael Brandt
Ghostface
Dane Farwell
Deputy Jenkins
Gordon Michaels
Mr. Baker
John Lepard
Reporter #2
Kim Adams
Reporter #3
Devin Scillian
Dr. Orth
Mark Aaron Buerkle
Reporter #1
Julia Ho
Cocky Student
Alexander Punch
Reporter #4
Glenda Lewis
Reporter #5
William Spencer
Reporter #6
Tim Doty
Reporter #7
Peter Carey
Coroner (uncredited)
Wes Craven