The ongoing war between the canine and feline species is put on hold when they join forces to thwart a rogue cat spy with her own sinister plans for conquest.
Diggs (voice)
James Marsden
Butch (voice)
Nick Nolte
Catherine (voice)
Christina Applegate
Kitty Galore (voice)
Bette Midler
Jackie
Pascale Hutton
Seamus (voice)
Katt Williams
Lou (voice)
Neil Patrick Harris
Mr. Tinkles (voice)
Sean Hayes
Calico (voice)
Wallace Shawn
Tab Lazenby (voice)
Roger Moore
Peek (voice)
Joe Pantoliano
Sam (voice)
Michael Clarke Duncan
Shane
Chris O'Donnell
Chuck
Jack McBrayer
Freidrich
Fred Armisen
Little Girl
Kiernan Shipka
Crazy Carlito (voice)
Paul Rodríguez
Gruff K-9 (voice)
J.K. Simmons
Security Bulldog/Catherine's Niece/Cat Spy Analyst
Grey DeLisle
Scrumptious / Patches / Catherine's Niece (voice)
E. G. Daily
Paws / Cat Spy Analyst (voice)
Phil LaMarr
Angus MacDougall (voice)
Michael Beattie
Duncan MacDougall (voice)
Jeff Bennett
Captain Flemming
Malcolm Stewart
Reporter
Dawn Chubai
Coit Tower Guard
Keith Dallas
Rex (voice)
Len Morganti
Cat Lady
Betty Phillips
Hep Cat / Cat Spy Analyst (voice)
Christopher Lee Parson
Cool Cat / Dog Killa / Cat Spy Analyst / Slim (voice)
Bumper Robinson
Rocky (voice)
Rick D. Wasserman
Inmate Fat Cat (voice)
Roger L. Jackson
Dog HQ PA / Catherine's Niece (voice)
Bonnie Cahoon
Snobby K-9 (voice)
André Sogliuzzo
Cat Gunner / Cat Spy Analyst (voice)
Carlos Alazraqui
Security Bulldog / Catherine's Niece / Cat Spy Analyst (voice)
Grey DeLisle
Mom
Ingrid Tesch
Playland Worker
Amitai Marmorstein
Old Man
Robert Hewko
Used Car Salesman
Mark Burgess
Park Patron
Sage Brocklebank