A sorority moves in next door to the home of Mac and Kelly Radner who have a young child. The Radner's enlist their former nemeses from the fraternity to help battle the raucous sisters.
Mac Radner
Seth Rogen
Teddy Sanders
Zac Efron
Kelly Radner
Rose Byrne
Shelby
Chloë Grace Moretz
Pete
Dave Franco
Jimmy
Ike Barinholtz
Dean Carol Gladstone
Lisa Kudrow
Phi Lamda President
Selena Gomez
Garf
Jerrod Carmichael
Paula
Carla Gallo
Beth
Kiersey Clemons
Nora
Beanie Feldstein
Officer Watkins
Hannibal Buress
Scoonie
Christopher Mintz-Plasse
Stella
Elise Vargas
Stella
Zoey Vargas
Maranda
Clara Mamet
Christine
Awkwafina
Darren
John Early
Frat President
Johnny Pemberton
R.A.
Kyle Mooney
Second Frat Guy
Ian Gregg
Live Tinder Guy
Jacob Wysocki
Wendy the Realtor
Liz Cackowski
Shelby's Dad
Kelsey Grammer
Eric Baiers
Sam Richardson
Jessica Baiers
Abbi Jacobson
Oliver Studebaker
Billy Eichner
Bill Wazakowski
Brian Huskey
Rapper
Miles Armstrong
Rapper
Kemuel Crossty
Rapper
Cameron Hill
Rapper
Denryc Hill
Rapper
Brian K. Johnson
Rapper
Windsor Jones
Rapper
Harrison Thacker
Sorority Girl
Ciara Bravo