Seven years after the defeat of the spiral king, Simon and the Dai-Gurren brigade must set out to the vastness of space to defeat a new threat and save the universe.
Simon (voice)
Tetsuya Kakihara
Nia Teppelin (voice)
Yukari Fukui
Yoko Littner (voice)
Marina Inoue
Kamina (voice)
Katsuyuki Konishi
Leeron Littner (voice)
Masaya Onosaka
Rossiu Adai (voice)
Mitsuki Saiga
Viral (voice)
Nobuyuki Hiyama
Boota (voice) / Darry Adai (voice)
Shizuka Itoh
Darry Adai (voice) / Leite Jokin (voice)
Takako Honda
Kittan Bachika (voice)
Kisho Taniyama
Kiyoh Bachika (voice)
Rina Sato
Kinon Bachika (voice)
Kana Ueda
Kiyal Bachika (voice)
Kana Asumi
Anti-Spiral (voice)
Takaya Kamikawa
Lordgenome (voice)
Narushi Ikeda
Old Coco (voice)
Nobuyuki Hiyama
Attenborough Cortich (voice) / Iraak Coega (voice)
Daisuke Kirii
Zoushi Kanai (voice)
Takafumi Kawakami
Gabal Docker (voice) / Jorgun Bakusa (voice)
Go Shinomiya
Kid Coega (voice)
Takashi Kondo
Tetsukan Littner
Takahiro Mizushima
Balinbow Bakusa (voice)
Kouzou Douzaka
Makken Jokin (voice)
Katsuyuki Konishi
Cybela Kuto (voice)
Haruhi Nanao
Guinble Kaito (voice)
Takahiro Mizushima