When the renegade crew of Serenity agrees to hide a fugitive on their ship, they find themselves in an action-packed battle between the relentless military might of a totalitarian regime who will destroy anything – or anyone – to get the girl back and the bloodthirsty creatures who roam the uncharted areas of space. But... the greatest danger of all may be on their ship.
Malcolm 'Mal' Reynolds
Nathan Fillion
River Tam
Summer Glau
Zoë Alleyne Washburne
Gina Torres
Hoban 'Wash' Washburne
Alan Tudyk
Inara Serra
Morena Baccarin
Jayne Cobb
Adam Baldwin
Kaywinnet Lee 'Kaylee' Frye
Jewel Staite
Simon Tam
Sean Maher
Shepherd Derrial Book
Ron Glass
The Operative
Chiwetel Ejiofor
Mr. Universe
David Krumholtz
Dr. Mathias
Michael Hitchcock
Dr. Caron
Sarah Paulson
Mingojerry 'Mingo' Rample
Yan Feldman
Fantastic "Fanty" Rample
Rafael Feldman
Lenore
Nectar Rose
Teacher
Tamara Taylor
Lilac Young Tough
Glenn Howerton
Young River Tam
Hunter Ansley Wryn
Boy Student
Logan O'Brien
Boy Student
Erik Erotas
Girl Student
Demetra Raven
Girl Student
Marley McClean
Girl Student
Jessica Huang
Ensign
Scott Kinworthy
Helmsman
Erik Weiner
Lab Technician
Conor O'Brien
Lab Technician
Peter James Smith
Trade Agent
Weston Nathanson
Young Female Intern
Carrie "CeCe" Cline
Vault Guard
Chuck O'Neil
Lilac Mom
Amy Wieczorek
Lilac Son
Tristan Jarred
Fan Dancer
Elaine Mani Lee
Mining Camp Boy
Terrence Hardy Jr.
Alliance Pilot
Brian O'Hare
Black Room Soldier
Ryan Tasz
Black Room Soldier
Colin Patrick Lynch
News Anchor
Terrell Tilford
Slovenly Beaumonde Man
Joshua Michael Kwiat
Bartender (uncredited)
Antonio Rufino
Chinese Snake Dancer (uncredited)
Linda Wang
Bar Guy (uncredited)
Rick Williamson
Screaming Reaver (uncredited)
Neil Patrick Harris
Lab Security (uncredited)
Matt McColm
Bar Security (uncredited)
Marcus Young
Bar Guy (uncredited)
Dennis Keiffer
Futuristic Worker (uncredited)
Mark Winn