The advent of new weight loss drugs has a huge impact on everyone in South Park. When Cartman is denied access to the life-changing medicine, the kids jump into action.
Stan Marsh / Eric Cartman (voice)
Trey Parker
Kyle Broflovski / Kenny McCormick / Butters Stotch / Gerald Broflovski (voice)
Matt Stone
Wendy Testaburger / Sharon Marsh / Shelley Marsh / Liane Cartman / Alexis Testaburger (voice)
April Stewart
Sheila Broflovski / Mrs. Tweak / Linda Stotch (voice)
Mona Marshall
Laura Tucker / Linda Black (voice)
Kimberly Brooks
Additional Voices (voice)
Jessica Makinson
Towelie (voice)
Vernon Chatman
Additional Voices (voice)
Jennifer Howell
Additional Voices (voice)
Feraz Ozel Ellahie
Additional Voices (voice)
Betty Boogie Parker
Additional Voices (voice)
Abdullah Saeed
Self (archive footage) (uncredited)
Kyle Richards
Self (archive footage) (uncredited)
Oprah Winfrey